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Thyroid Peroxidase(TPO)

Product code: EM60135

  • Overview

  • Product name Thyroid Peroxidase(TPO)
  • Molecular Wt 103 kDa
  • Description roglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones. In humans, thyroperoxidase is encoded by the TPO gene. Inorganic iodine enters the body primarily as iodide, I−. After entering the thyroid follicle (or thyroid follicular cell) via a Na+/I− symporter (NIS) on the basolateral side, iodide is shuttled across the apical membrane into the colloid via pendrin, after which thyroid peroxidase oxidizes iodide to atomic iodine (I) or iodinium (I+). The "organification of iodine," the incorporation of iodine into thyroglobulin for the production of thyroid hormone, is nonspecific; that is, there is no TPO-bound intermediate, but iodination occurs via reactive iodine species released from TPO. The chemical reactions catalyzed by thyroid peroxidase occur on the outer apical membrane surface and are mediated by hydrogen peroxide.
  • Species reactivity Human
  • Tested applications IHC-P
  • Antibody type Mouse Monoclonal Antibody
  • Immunogen Synthesized peptide derived from human Thyroid Peroxidase(TPO)
  • Positive control Glandular pool- thyroid, Spleen, Thyroid.
  • Conjugate Non-conjugated
  • Alternative names MSA antibody
    PERT_HUMAN antibody
    TDH2A antibody
    Thyroid microsomal antigen antibody
    Thyroid peroxidase antibody
    Thyroperoxidase antibody
    TPO antibody
    TPX antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Purity Immunogen affinity purified.
  • Subcellular location Membrane.
  • Database links SwissProt: P07202 Human
  • Applications

    IHC-P: 1:100-1:500

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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